The saturation dose in many studies about the GHRPs (GHRP-6, GHRP-2, Ipamorelin & Hexarelin) is defined as either 100mcg or 1mcg/kg.
What which means is the fact that 100mcg will saturate the receptors fully, however, if you set another 100mcg fot it dose only 50% of the portion will be effective. Should you add one more 100mcg to that dose just about 25% will probably be effective. Perhaps a final 100mcg might put in a little something to GH release that is it.
So 100mcg is the saturation dose as well as increase the amount of around 300 to 400mcg and obtain a bit more effect.
A 500mcg dose are not more effective a 400mcg, perhaps even if it’s just more effective then 300mcg.
Any additional troubles are desensitization & cortisol/prolactin side-effects.
cabergoline is about as efficacious as GHRP-6 in causing GH release but even at higher dose (above 100mcg) this doesn’t create prolactin or cortisol.
GHRP-6 with the saturation dose 100mcg will not really increase prolactin & cortisol but may do so slightly at higher doses. This rise remains to be within the normal range.
GHRP-2 is a bit more efficacious then GHRP-6 at causing GH release but at the saturation dose or higher may produce a slight to moderate rise in prolactin & cortisol. This rise remains from the normal range although doses of 200 – 400mcg might make it the high end from the normal range.
Hexarelin is among the most efficacious out of all the GHRPs at causing an increase in GH release. Nevertheless it contains the highest potential to may also increase cortisol & prolactin. This rise will occur even on the 100mcg saturation dose. This rise will get to the higher numbers of precisely what is looked as normal.
GHRP-6 works extremely well at saturation dose (100mcg) 3 to 4 times per day without probability of desensitization.
GHRP-2 probably at saturation dose more than once a day will not likely bring about desensitization.
Hexarelin has been shown to create desensitization but also in a long-term read the pituitary recovered its sensitivity so that there were not long-term lack of sensitivity at saturation dose. However dosing Hexarelin even at 100mcg 3 times every day may lead to some down regulation within Two weeks.
If desensitization would ever occur for any of those GHRPs simply stopping use during their visit will remedy this effect.
Chronic using GHRP-6 at 100mcg dosed repeatedly per day every day won’t cause pituitary problems, nor significant prolactin or cortisol problems, nor desensitize.
Now Sermorelin, GHRH (1-44) and GRF(1-29) each is basically GHRH and have a short half-life in plasma as a result of quick cleavage between the 2nd & 3rd protein. That is no worry naturally because this hormone is secreted through the hypothalamus and travels ten or twenty yards on the underlying anterior pituitary and is not really subject to enzymatic cleavage. The production from the hypothalamus and binding to somatotrophs (pituitary cells) happens quickly.
However, if injected to the body it has to circulate before finding its approach to the pituitary so within 3 minutes it is already being degraded.
That’s the reason GHRH within the above forms has to be dosed high to get a result.
All GHRH analogs swap Alanine in the 2nd position for D-Alanine helping to make the peptide resistant to quick cleavage at this position. This implies analogs is often more effective when injected at smaller dosing.
The analog tetra or 4 substituted GRF(1-29) sometimes called CJC w/o the DAC or described by me as modified GRF(1-29) has other amino acid modifications. They are a glutamine (Gln or Q) at the 8-position, alanine (Ala or A) in the 15-position, as well as a leucine (Leu or L) with the 27-position.
The alanine with the 8th position enhances bioavailability nevertheless the other two amino substitutions are made to increase the manufacturing process (i.e. create manufacturing stability).
For use in vivo, in humans, the GHRH analog known as CJC w/o the DAC or tetra (4) substituted GRF(1-29) or modified GRF(1-29) is a very effective peptide with a half-life probably 30+ minutes.
Which is long enough being completely effective.
The saturation dose can also be understood to be 100mcg.
Problem w/ Using any GHRH alone
The problem with utilizing a GHRH the stronger analogs is that they are just successful when somatostatin is low (the GH inhibiting hormone). If you unluckily administer in a trough (or every time a GH pulse just isn’t naturally sourced) you may add little or no GH release. If however you luckily administer after a rising wave or GH pulse (somatostatin will not be active now) you are going to increase GH release.
Solution is GHRP + GHRH analog
The answer is simple and highly effective. You administer a GHRH analog having a GHRP. The GHRP results in a pulse of GH. It lets you do this through several mechanisms. One mechanism is the lowering of somatostatin release through the hypothalamus, this band are brilliant a rebate of somatostatin influence at the pituitary, still another is increased launch of GHRH through the brain lastly GHRPs act on the same pituitary cells (somatotrophs) as do GHRHs but utilize a different mechanism to raise cAMP formation that will further cause GH release from somatotroph stores.
GHRH even offers a way of reciprocally reinforcing GHRPs action.
It feels right a synergistic GH release.
The GH just isn’t additive it’s synergistic. By that I mean:
If GHRH on it’s own may cause a GH release worth 2
and GHRP itself may cause a GH release valued at 5
Together the GH isn’t 7 (5+2) as it turns out to say 16!
A solid protocol
A solid protocol is always to make use of a GHRP + a GHRH analog pre-bed (to guide the nightime pulse) and when or twice the whole day.
For anti-aging, deep restful restorative sleep, the once at night dosing is all you will need. To have an adult aged 40+ it’s enough to regenerate GH to youthful levels.
But also for bodybuilding or fatloss or injury repair multiple dosings could be effective.
The GHRH analog can be utilized at 100mcg in addition to being high as you would like without difficulty.
The GHRP-6 can invariably be used at 100mcg w/o problems but a dose of 200mcg is going to be fine as well.
Again desensitization is one area to maintain an eye on particularly using the highest doses of GHRP-2 and all doses of Hexarelin.
So 100 – 200mcg of GHRP-6 + 100 – 500mcg+ of the GHRH analog taken together will likely be effective.
This can be dosed repeatedly each day to get successful.
A solid approach is more conservative at 100mcg of GHRP-6 + 100mcg of a GHRH analog dosed either once, twice, 3 to 4 times every day.
When dosing multiple times each day no less than 3 hours should separate the administrations.
The gap is once a day dosing pre-bed can give a young restorative volume of GH while multiple dosing and even higher levels gives higher GH & IGF-1 levels when as well as diet & exercise will lead to muscle gain & fatloss.
Dose w/o food
Administration should ideally be done on either an empty stomach or with simply protein from the stomach. Fats & carbs blunt GH release. So administer the peptides and wait about 20 mins (no longer then 30 but truth be told then Fifteen minutes) to consume. When this occurs the GH pulse has about hit the peak and you may eat what you would like.
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